Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

Tumor cells trends to express high level of pyruvate kinase M2 (PKM2). The inhibition of PKM2 activity is needed for antioxidant response by diverting glucose flux into the pentose phosphate pathway and thus generating sufficient reducing potential. Here we report that PKM2 is succinylated at lysine...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Xiangyun, Ye, Xiaomin, Niu, linping, Gu, Yunhua, Xu, Ziming, Li, Yongfeng, Yu, Zhiwei, Chen, Shun, Lu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2016
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351684/
https://ncbi.nlm.nih.gov/pubmed/28036303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14346
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