Glutathione restricts serine metabolism to preserve regulatory T cell function

Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network (1CMet) essential for effector T cell (Teff) responses. However, serine’s functions, linkage to GSH, and role in stress respo...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Kurniawan, Henry, Franchina, Davide G., Guerra, Luana, Bonetti, Lynn, Soriano-Baguet, Leticia, Grusdat, Melanie, Schlicker, Lisa, Hunewald, Oliver, Dostert, Catherine, Merz, Myriam P., Binsfeld, Carole, Duncan, Gordon S., Farinelle, Sophie, Nonnenmacher, Yannic, Haight, Jillian, Gupta, Dennis Das, Ewen, Anouk, Taskesen, Rabia, Halder, Rashi, Chen, Ying, Jäger, Christian, Ollert, Markus, Wilmes, Paul, Vasiliou, Vasilis, Harris, Isaac S., Knobbe-Thomsen, Christiane B., Turner, Jonathan D., Mak, Tak W., Lohoff, Michael, Meiser, Johannes, Hiller, Karsten, Brenner, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265172/
https://ncbi.nlm.nih.gov/pubmed/32213345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.03.004
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