Engineered Circular RNA Sponges Act as miRNA Inhibitors to Attenuate Pressure Overload-Induced Cardiac Hypertrophy

Circular RNAs (circRNAs) sequester microRNAs (miRNAs) and repress their endogenous activity. We hypothesized that artificial circRNA sponges (circmiRs) can be constructed to target miRNAs therapeutically, with a low dosage requirement and extended half-lives compared to current alternatives. This co...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther
Hauptverfasser: Lavenniah, Annadoray, Luu, Tuan Danh Anh, Li, Yiqing Peter, Lim, Tingsen Benson, Jiang, Jianming, Ackers-Johnson, Matthew, Foo, Roger S.-Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264434/
https://ncbi.nlm.nih.gov/pubmed/32304667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.04.006
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