AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex

Bacteria have evolved sophisticated adaptive immune systems, called CRISPR-Cas, that provide sequence-specific protection against phage infection. In turn, phages have evolved a broad spectrum of anti-CRISPRs that suppress these immune systems. Here we report structures of anti-CRISPR protein IF9 (A...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Hirschi, Marscha, Lu, Wang-Ting, Santiago-Frangos, Andrew, Wilkinson, Royce, Golden, Sarah M., Davidson, Alan R., Lander, Gabriel C., Wiedenheft, Blake
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264359/
https://ncbi.nlm.nih.gov/pubmed/32483187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16512-1
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