Chronic expression of p16(INK4a) in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation

p16(INK4a) (CDKN2A) is a central tumor suppressor, which induces cell-cycle arrest and senescence. Cells expressing p16(INK4a) accumulate in aging tissues and appear in premalignant lesions, yet their physiologic effects are poorly understood. We found that prolonged expression of transgenic p16(INK...

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發表在:Nat Commun
Main Authors: Azazmeh, Narmen, Assouline, Benjamin, Winter, Eitan, Ruppo, Shmuel, Nevo, Yuval, Maly, Alexander, Meir, Karen, Witkiewicz, Agnieszka K., Cohen, Jonathan, Rizou, Sophia V., Pikarsky, Eli, Luxenburg, Chen, Gorgoulis, Vassilis G., Ben-Porath, Ittai
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264228/
https://ncbi.nlm.nih.gov/pubmed/32483135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16475-3
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