p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion

Cellular senescence is thought to contribute to age-associated deterioration of tissue physiology. The senescence effector p16(Ink4a) is expressed in pancreatic beta cells during aging and limits their proliferative potential; however, its effects on beta cell function are poorly characterized. We f...

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Veröffentlicht in:Nat Med
Hauptverfasser: Helman, Aharon, Klochendler, Agnes, Azazmeh, Narmen, Gabai, Yael, Horwitz, Elad, Anzi, Shira, Swisa, Avital, Condiotti, Reba, Granit, Roy Z, Nevo, Yuval, Fixler, Yaakov, Shreibman, Dorin, Zamir, Amit, Tornovsky-Babeay, Sharona, Dai, Chunhua, Glaser, Benjamin, Powers, Alvin C, Shapiro, A M James, Magnuson, Mark A, Dor, Yuval, Ben-Porath, Ittai
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546206/
https://ncbi.nlm.nih.gov/pubmed/26950362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4054
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