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Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

T cells react to foreign or self-antigens through T cell receptor (TCR) signaling. Several decades of research have delineated the mechanism of TCR signal transduction and its impact on T cell performance. This knowledge provides the foundation for chimeric antigen receptor T cell (CAR-T cell) techn...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Immunol
Autori principali: Wu, Ling, Wei, Qianru, Brzostek, Joanna, Gascoigne, Nicholas R. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264185/
https://ncbi.nlm.nih.gov/pubmed/32451454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-0470-3
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