Engineering bionic T cells: signal 1, signal 2, signal 3, reprogramming and the removal of inhibitory mechanisms

Gene engineering and combinatorial approaches with other cancer immunotherapy agents may confer capabilities enabling full tumor rejection by adoptive T cell therapy (ACT). The provision of proper costimulatory receptor activity and cytokine stimuli, along with the repression of inhibitory mechanism...

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Bibliografiske detaljer
Udgivet i:Cell Mol Immunol
Main Authors: Etxeberria, Iñaki, Olivera, Irene, Bolaños, Elixabet, Cirella, Asunta, Teijeira, Álvaro, Berraondo, Pedro, Melero, Ignacio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264123/
https://ncbi.nlm.nih.gov/pubmed/32433539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-0464-1
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