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HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters

Objectives: Viral phylogenetics revealed two patterns of HIV-1 spread among MSM in Quebec. While most HIV-1 strains (n = 2011) were associated with singleton/small clusters (cluster size 1–4), 30 viral lineages formed large networks (cluster size 20–140), contributing to 42% of diagnoses between 201...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Brenner, Bluma G., Ibanescu, Ruxandra-Ilinca, Oliveira, Maureen, Roger, Michel, Hardy, Isabelle, Routy, Jean-Pierre, Kyeyune, Fred, Quiñones-Mateu, Miguel E., Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263826/
https://ncbi.nlm.nih.gov/pubmed/28472323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx118
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