Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae

The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN) in yeast, fly, and human cells and CENP-A is hig...

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Vydáno v:G3 (Bethesda)
Hlavní autoři: Eisenstatt, Jessica R., Boeckmann, Lars, Au, Wei-Chun, Garcia, Valerie, Bursch, Levi, Ocampo, Josefina, Costanzo, Michael, Weinreich, Michael, Sclafani, Robert A., Baryshnikova, Anastasia, Myers, Chad L., Boone, Charles, Clark, David J., Baker, Richard, Basrai, Munira A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2020
Témata:
Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263675/
https://ncbi.nlm.nih.gov/pubmed/32295767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.120.401131
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