Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells

Chromosomal instability (CIN) is a hallmark of many cancers and a major contributor to tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily conserved centromeric histone H3 variant CENP-A, associate with centromeric DNA for centromere function and chromosomal stab...

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Udgivet i:Oncotarget
Main Authors: Shrestha, Roshan L., Ahn, Grace S., Staples, Mae I., Sathyan, Kizhakke M., Karpova, Tatiana S., Foltz, Daniel R., Basrai, Munira A.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper: Chromosome
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564523/
https://ncbi.nlm.nih.gov/pubmed/28596481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18108
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