Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomal instability in Saccharomyces cerevisiae

Mislocalization of the centromeric histone H3 variant (Cse4 in budding yeast, CID in flies, CENP-A in humans) to noncentromeric regions contributes to chromosomal instability (CIN) in yeast, fly, and human cells. Overexpression and mislocalization of CENP-A have been observed in cancers, however, th...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Eisenstatt, Jessica R, Ohkuni, Kentaro, Au, Wei-Chun, Preston, Olivia, Gliford, Loran, Suva, Evelyn, Costanzo, Michael, Boone, Charles, Basrai, Munira A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128410/
https://ncbi.nlm.nih.gov/pubmed/33751052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/genetics/iyab033
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