Thrombopoietin is required for full phenotype expression in a JAK2(V617F) transgenic mouse model of polycythemia vera

The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver mutations that either directly activate the thrombopoietin receptor, MPL, or activate it indirectly through gain-of-function mutations in the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Spivak, Jerry L., Merchant, Akil, Williams, Donna M., Rogers, Ophelia, Zhao, Wanke, Duffield, Amy, Resar, Linda S., Moliterno, Alison R., Zhao, Zhizhuang J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263591/
https://ncbi.nlm.nih.gov/pubmed/32479500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232801
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