Thrombopoietin is required for full phenotype expression in a JAK2(V617F) transgenic mouse model of polycythemia vera

The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver mutations that either directly activate the thrombopoietin receptor, MPL, or activate it indirectly through gain-of-function mutations in the...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Spivak, Jerry L., Merchant, Akil, Williams, Donna M., Rogers, Ophelia, Zhao, Wanke, Duffield, Amy, Resar, Linda S., Moliterno, Alison R., Zhao, Zhizhuang J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263591/
https://ncbi.nlm.nih.gov/pubmed/32479500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232801
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