Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression

An activating JAK2 mutation (JAK2 V617F) is present in the chronic myeloproliferative disorders (MPDs), polycythemia vera (PV), idiopathic myelofibrosis (IMF), and essential thrombocytosis (ET). JAK2 is also a chaperone for Mpl and responsible for its cell-surface expression. We observed a reciproca...

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Bibliografiska uppgifter
Huvudupphovsmän: Moliterno, Alison R., Williams, Donna M., Rogers, Ophelia, Spivak, Jerry L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society of Hematology 2006
Ämnen:
Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895466/
https://ncbi.nlm.nih.gov/pubmed/16912229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-008805
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