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Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation
Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species (ROS). These ROS then oxidize cysteine residues in proteins to potentiate downstream signaling. Spatial confinement of ROS...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7263378/ https://ncbi.nlm.nih.gov/pubmed/31964804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay7315 |
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