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Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators
Allosteric drugs, which bind to proteins in regions other than their main ligand-binding or active sites, make it possible to target proteins considered “undruggable” and to develop new therapies that circumvent existing resistance. Despite growing interest in allosteric drug discovery, rational des...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5453556/ https://ncbi.nlm.nih.gov/pubmed/28570708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178678 |
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