Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation

Stimulation of plasma membrane receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR), locally increases the abundance of reactive oxygen species (ROS). These ROS then oxidize cysteine residues in proteins to potentiate downstream signaling. Spatial confinement of ROS...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Signal
Prif Awduron: Behring, Jessica B., van der Post, Sjoerd, Mooradian, Arshag D., Egan, Matthew J., Zimmerman, Maxwell I., Clements, Jenna L., Bowman, Gregory R., Held, Jason M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263378/
https://ncbi.nlm.nih.gov/pubmed/31964804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aay7315
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