Global fitness landscapes of the Shine-Dalgarno sequence

Shine-Dalgarno sequences (SD) in prokaryotic mRNA facilitate protein translation by pairing with rRNA in ribosomes. Although conventionally defined as AG-rich motifs, recent genomic surveys reveal great sequence diversity, questioning how SD functions. Here, we determined the molecular fitness (i.e....

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Podrobná bibliografie
Vydáno v:Genome Res
Hlavní autoři: Kuo, Syue-Ting, Jahn, Ruey-Lin, Cheng, Yuan-Ju, Chen, Yi-Lan, Lee, Yun-Ju, Hollfelder, Florian, Wen, Jin-Der, Chou, Hsin-Hung David
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263185/
https://ncbi.nlm.nih.gov/pubmed/32424071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.260182.119
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