Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

Mutations in the adenomatous polyposis coli (APC) gene are common in colorectal cancer (CRC), and more than 90% of those mutations generate stable truncated gene products. We describe a chemical screen using normal human colonic epithelial cells (HCECs) and a series of oncogenically progressed HCECs...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Zhang, Lu, Theodoropoulos, Panayotis C., Eskiocak, Ugur, Wang, Wentian, Moon, Young-Ah, Posner, Bruce, Williams, Noelle S., Wright, Woodring E., Kim, Sang Bum, Nijhawan, Deepak, De Brabander, Jef K., Shay, Jerry W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262871/
https://ncbi.nlm.nih.gov/pubmed/27798265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf8127
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