Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

Carfilzomib-loaded polymeric micelles (CFZ-PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared with the aim to improve the maximum tolerated dose of carfilzomib in a “humanized” bone marrow-like scaffold model. For this, CFZ-PM were prepar...

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Dettagli Bibliografici
Pubblicato in:Int J Pharm X
Autori principali: Varela-Moreira, Aida, van Straten, Demian, van Leur, Heleen F., Ruiter, Ruud W.J., Deshantri, Anil K., Hennink, Wim E., Fens, Marcel H.A.M., Groen, Richard W.J., Schiffelers, Raymond M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262453/
https://ncbi.nlm.nih.gov/pubmed/32490374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpx.2020.100049
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