A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy

Colchicinoids are very potent tubulin-binding compounds, which interfere with microtubule formation, giving them strong cytotoxic properties, such as cell mitosis inhibition and induction of microcytoskeleton depolymerization. While this makes them promising vascular disrupting agents (VDAs) in canc...

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Bibliografski detalji
Glavni autori: Crielaard, Bart J, van der Wal, Steffen, Lammers, Twan, Le, Huong Thu, Hennink, Wim E, Schiffelers, Raymond M, Storm, Gert, Fens, Marcel HAM
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2011
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Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218583/
https://ncbi.nlm.nih.gov/pubmed/22114500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S24450
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