A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy

Colchicinoids are very potent tubulin-binding compounds, which interfere with microtubule formation, giving them strong cytotoxic properties, such as cell mitosis inhibition and induction of microcytoskeleton depolymerization. While this makes them promising vascular disrupting agents (VDAs) in canc...

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Detalhes bibliográficos
Main Authors: Crielaard, Bart J, van der Wal, Steffen, Lammers, Twan, Le, Huong Thu, Hennink, Wim E, Schiffelers, Raymond M, Storm, Gert, Fens, Marcel HAM
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218583/
https://ncbi.nlm.nih.gov/pubmed/22114500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S24450
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