A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin

Aberrant epigenetic modifications are involved in cancer development. Jumonji C domain-containing histone lysine demethylases (KDMs) are found mainly up-regulated in breast, prostate, and colon cancer. Currently, growing interest is focusing on the identification and development of new inhibitors ab...

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Publicat a:Front Chem
Autors principals: Souto, José A., Sarno, Federica, Nebbioso, Angela, Papulino, Chiara, Álvarez, Rosana, Lombino, Jessica, Perricone, Ugo, Padova, Alessandro, Altucci, Lucia, de Lera, Ángel R.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261929/
https://ncbi.nlm.nih.gov/pubmed/32523934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00312
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