Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart

We have previously demonstrated that ischemia/reperfusion (I/R) impairs endoplasmic reticulum (ER)-based protein folding in the heart and thereby activates an unfolded protein response sensor and effector, activated transcription factor 6α (ATF6). ATF6 then induces mesencephalic astrocyte-derived ne...

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Publicado en:J Biol Chem
Autores principales: Arrieta, Adrian, Blackwood, Erik A., Stauffer, Winston T., Santo Domingo, Michelle, Bilal, Alina S., Thuerauf, Donna J., Pentoney, Amber N., Aivati, Cathrine, Sarakki, Anup V., Doroudgar, Shirin, Glembotski, Christopher C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261788/
https://ncbi.nlm.nih.gov/pubmed/32327487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013345
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