ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb

RATIONALE: ER stress dysregulates ER proteostasis, which activates the transcription factor, ATF6, an inducer of genes that enhance protein folding and restore proteostasis. Due to increased protein synthesis, it is possible that protein folding and, thus, ER proteostasis are challenged during cardi...

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Pubblicato in:Circ Res
Autori principali: Blackwood, Erik A., Hofmann, Christoph, Domingo, Michelle Santo, Bilal, Alina S., Sarakki, Anup, Stauffer, Winston, Arrieta, Adrian, Thuerauf, Donna J., Kolkhorst, Fred W., Müller, Oliver J., Jakobi, Tobias, Dieterich, Christoph, Katus, Hugo A., Doroudgar, Shirin, Glembotski, Christopher C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461398/
https://ncbi.nlm.nih.gov/pubmed/30582446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.313854
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