Targeted Donor Complement Blockade After Brain-Death Prevents Delayed Graft Function In A Non-Human Primate Model Of Kidney Transplantation.

Delayed graft function (DGF) in renal transplantation is associated with reduced graft survival and increased immunogenicity. The complement-driven inflammatory response after brain death (BD) and post-transplant reperfusion injury play significant roles in the pathogenesis of DGF. In a non-human pr...

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Pubblicato in:Am J Transplant
Autori principali: Danobeitia, Juan S., Zens, Tiffany J., Chlebeck, Peter J., Zitur, Laura J., Reyes, Jose A., Eerhart, Michael J., Coonen, Jennifer, Capuano, Saverio, D’Alessandro, Anthony M., Torrealba, Jose R., Burguete, Daniel, Brunner, Kevin, Amersfoort, EdwinVan, Ponstein-Simarro Doorten, Yolanda, Van Kooten, Cees, Jankowska-Gan, Ewa, Burlingham, William, Sullivan, Jeremy, Djamali, Arjang, Pozniak, Myron, Yankol, Yucel, Fernandez, Luis A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261643/
https://ncbi.nlm.nih.gov/pubmed/31922336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15777
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