Targeted Donor Complement Blockade After Brain-Death Prevents Delayed Graft Function In A Non-Human Primate Model Of Kidney Transplantation.

Delayed graft function (DGF) in renal transplantation is associated with reduced graft survival and increased immunogenicity. The complement-driven inflammatory response after brain death (BD) and post-transplant reperfusion injury play significant roles in the pathogenesis of DGF. In a non-human pr...

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izdano v:Am J Transplant
Main Authors: Danobeitia, Juan S., Zens, Tiffany J., Chlebeck, Peter J., Zitur, Laura J., Reyes, Jose A., Eerhart, Michael J., Coonen, Jennifer, Capuano, Saverio, D’Alessandro, Anthony M., Torrealba, Jose R., Burguete, Daniel, Brunner, Kevin, Amersfoort, EdwinVan, Ponstein-Simarro Doorten, Yolanda, Van Kooten, Cees, Jankowska-Gan, Ewa, Burlingham, William, Sullivan, Jeremy, Djamali, Arjang, Pozniak, Myron, Yankol, Yucel, Fernandez, Luis A.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261643/
https://ncbi.nlm.nih.gov/pubmed/31922336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15777
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