Complement inhibition attenuates acute kidney injury after ischemia-reperfusion and limits progression to renal fibrosis in mice

The complement system is an essential component of innate immunity and plays a major role in the pathogenesis of ischemia-reperfusion injury (IRI). In this study, we investigated the impact of human C1-inhibitor (C1INH) on the early inflammatory response to IRI and the subsequent progression to fibr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Danobeitia, Juan S., Ziemelis, Martynas, Ma, Xiaobo, Zitur, Laura J., Zens, Tiffany, Chlebeck, Peter J., Van Amersfoort, Edwin S., Fernandez, Luis A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568291/
https://ncbi.nlm.nih.gov/pubmed/28832655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183701
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