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E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation
Hedgehog (Hh) signalling plays conserved roles in controlling embryonic development; its dysregulation causes many diseases including cancers. The G protein-coupled receptor Smoothened (Smo) is the key signal transducer of the Hh pathway, whose posttranslational regulation has been shown to be criti...
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| Publicado no: | J Mol Cell Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261483/ https://ncbi.nlm.nih.gov/pubmed/30925584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz024 |
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