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Biased signaling by endogenous opioid peptides

Opioids, such as morphine and fentanyl, are widely used for the treatment of severe pain; however, prolonged treatment with these drugs leads to the development of tolerance and can lead to opioid use disorder. The “Opioid Epidemic” has generated a drive for a deeper understanding of the fundamental...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gomes, Ivone, Sierra, Salvador, Lueptow, Lindsay, Gupta, Achla, Gouty, Shawn, Margolis, Elyssa B., Cox, Brian M., Devi, Lakshmi A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261131/
https://ncbi.nlm.nih.gov/pubmed/32393639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000712117
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