Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior

Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the formation of membraneless organelles, which compartmentalize molecules intracellularly in the absence of a lipid membrane. Identifying the protein sequence features responsible for IDP phase separation is critical fo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Schuster, Benjamin S., Dignon, Gregory L., Tang, Wai Shing, Kelley, Fleurie M., Ranganath, Aishwarya Kanchi, Jahnke, Craig N., Simpkins, Alison G., Regy, Roshan Mammen, Hammer, Daniel A., Good, Matthew C., Mittal, Jeetain
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261017/
https://ncbi.nlm.nih.gov/pubmed/32393642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000223117
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