Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior

Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the formation of membraneless organelles, which compartmentalize molecules intracellularly in the absence of a lipid membrane. Identifying the protein sequence features responsible for IDP phase separation is critical fo...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Schuster, Benjamin S., Dignon, Gregory L., Tang, Wai Shing, Kelley, Fleurie M., Ranganath, Aishwarya Kanchi, Jahnke, Craig N., Simpkins, Alison G., Regy, Roshan Mammen, Hammer, Daniel A., Good, Matthew C., Mittal, Jeetain
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261017/
https://ncbi.nlm.nih.gov/pubmed/32393642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000223117
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