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Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations

Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly consist of RNA and RNA-binding proteins and are formed via liquid–liquid phase separation (LLPS). Experimental studies investigating the drivers of LLPS have shown that intrinsically disordered proteins (IDPs) and nuc...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Regy, Roshan Mammen, Dignon, Gregory L, Zheng, Wenwei, Kim, Young C, Mittal, Jeetain
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736803/
https://ncbi.nlm.nih.gov/pubmed/33264400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1099
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