Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens

Several candidate HIV subunit vaccines based on recombinant envelope (Env) glycoproteins have been advanced into human clinical trials. To facilitate biopharmaceutical production, it is necessary to produce these in CHO (Chinese Hamster Ovary) cells, the cellular substrate used for the manufacturing...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Li, Sophia W., Wright, Meredith, Healey, John F., Hutchinson, Jennie M., O’Rourke, Sara, Mesa, Kathryn A., Lollar, Pete, Berman, Phillip W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259603/
https://ncbi.nlm.nih.gov/pubmed/32470085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233866
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