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Leveraging atropisomerism to obtain a selective inhibitor of RET kinase with secondary activities towards EGFR mutants.
Unstable atropisomerism is innate in many common scaffolds in drug discovery, commonly existing as freely rotating aryl-aryl bonds. Such compounds can access the majority of dihedral conformations around the bond axis, however most small-molecules bind their target within a narrow range of these ava...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7259470/ https://ncbi.nlm.nih.gov/pubmed/31424197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00407 |
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