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Atropisomerism in medicinal chemistry: challenges and opportunities
Atropisomerism is a dynamic type of axial chirality that is ubiquitous in medicinal chemistry. There are several examples of stable atropisomeric US FDA-approved drugs and experimental compounds, and in each case the atropisomers of these compounds possess drastically different biological activities...
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| Publicado no: | Future Med Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Future Science Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5967358/ https://ncbi.nlm.nih.gov/pubmed/29380622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2017-0152 |
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