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Atropisomerism in medicinal chemistry: challenges and opportunities

Atropisomerism is a dynamic type of axial chirality that is ubiquitous in medicinal chemistry. There are several examples of stable atropisomeric US FDA-approved drugs and experimental compounds, and in each case the atropisomers of these compounds possess drastically different biological activities...

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Publicat a:Future Med Chem
Autors principals: Toenjes, Sean T, Gustafson, Jeffrey L
Format: Artigo
Idioma:Inglês
Publicat: Future Science Ltd 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967358/
https://ncbi.nlm.nih.gov/pubmed/29380622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2017-0152
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