Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based on transcriptome, we identified five distinct NK c...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: Yang, Chao, Siebert, Jason R, Burns, Robert, Zheng, Yongwei, Mei, Ao, Bonacci, Benedetta, Wang, Demin, Urrutia, Raul A, Riese, Matthew J, Rao, Sridhar, Carlson, Karen-Sue, Thakar, Monica S, Malarkannan, Subramaniam
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2020
Teme:
Immunology and Inflammation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255804/
https://ncbi.nlm.nih.gov/pubmed/32406817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51339
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