Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway

Histone deacetylase inhibitors (HDACi) are an emerging cancer therapy; however, their effect on natural killer (NK) cell-mediated anti-tumor responses remain unknown. Here, we evaluated the impact of a benzamide HDACi, entinostat, on human primary NK cells as well as tumor cell lines. Entinostat sig...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Idso, John M., Lao, Shunhua, Schloemer, Nathan J., Knipstein, Jeffrey, Burns, Robert, Thakar, Monica S., Malarkannan, Subramaniam
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244011/
https://ncbi.nlm.nih.gov/pubmed/32499867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27546
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