Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design

[Image: see text] HIV-1 protease is indispensable for virus propagation and an important therapeutic target for antiviral inhibitors to treat AIDS. As such inhibitors are transition-state mimics, a detailed understanding of the enzyme mechanism is crucial for the development of better anti-HIV drugs...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Kumar, Mukesh, Mandal, Kalyaneswar, Blakeley, Matthew P., Wymore, Troy, Kent, Stephen B. H., Louis, John M., Das, Amit, Kovalevsky, Andrey
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254801/
https://ncbi.nlm.nih.gov/pubmed/32478251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c00835
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