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An n→π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion Hole

Aspartic proteases regulate many biological processes and are prominent targets for therapeutic intervention. Structural studies have captured intermediates along the reaction pathway, including the Michaelis complex and tetrahedral intermediate. Using a Ramachandran analysis of these structures, we...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:ACS Catal
Hauptverfasser: Windsor, Ian W., Gold, Brian, Raines, Ronald T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513343/
https://ncbi.nlm.nih.gov/pubmed/31093467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.8b04142
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