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An n→π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion Hole
Aspartic proteases regulate many biological processes and are prominent targets for therapeutic intervention. Structural studies have captured intermediates along the reaction pathway, including the Michaelis complex and tetrahedral intermediate. Using a Ramachandran analysis of these structures, we...
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| Publicado no: | ACS Catal |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6513343/ https://ncbi.nlm.nih.gov/pubmed/31093467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.8b04142 |
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