Identification of the Biosynthetic Gene Cluster of Thermoactinoamides and Discovery of New Congeners by Integrated Genome Mining and MS-Based Molecular Networking

The putative non-ribosomal peptide synthetase (NRPS) gene cluster encoding the biosynthesis of the bioactive cyclohexapeptide thermoactinoamide A (1) was identified in Thermoactinomyces vulgaris DSM 43016. Based on an in silico prediction, the biosynthetic operon was shown to contain two trimodular...

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Publicado en:Front Chem
Autores principales: Della Sala, Gerardo, Mangoni, Alfonso, Costantino, Valeria, Teta, Roberta
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253712/
https://ncbi.nlm.nih.gov/pubmed/32528927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00397
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