Dysfunctional CD8+ T cells form a proliferative, dynamically regulated compartment within human melanoma

Tumor immune cell compositions play a major role in response to immunotherapy but the heterogeneity and dynamics of immune infiltrates in human cancer lesions remain poorly characterized. Here we identify conserved intratumoral CD4 and CD8 T cell behaviors in scRNA-seq data from 25 melanoma patients...

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Udgivet i:Cell
Main Authors: Li, Hanjie, van der Leun, Anne, Yofe, Ido, Lubling, Yaniv, Solodkin, Dikla Gelbard, van Akkooi, Alexander, van den Braber, Marlous, Rozeman, Lisette, Haanen, John, Blank, Christian, Horlings, Hugo M., David, Eyal, Baran, Yael, Bercovich, Akhiad, Lifshitz, Aviezer, Schumacher, Ton N., Tanay, Amos, Amit, Ido
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253294/
https://ncbi.nlm.nih.gov/pubmed/30595452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.043
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