Structural basis of broad HIV neutralization by a vaccine-induced cow antibody

Potent broadly neutralizing antibodies (bnAbs) to HIV have been very challenging to elicit by vaccination in wild-type animals. Here, by x-ray crystallography, cryo–electron microscopy, and site-directed mutagenesis, we structurally and functionally elucidate the mode of binding of a potent bnAb (NC...

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Pubblicato in:Sci Adv
Autori principali: Stanfield, Robyn L., Berndsen, Zachary T., Huang, Ruiqi, Sok, Devin, Warner, Gabrielle, Torres, Jonathan L., Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Smider, Vaughn V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253169/
https://ncbi.nlm.nih.gov/pubmed/32518821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba0468
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