Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

Amyloid aggregation of α-synuclein (α-syn) is closely associated with Parkinson’s disease (PD) and other synucleinopathies. Several single amino-acid mutations (e.g. E46K) of α-syn have been identified causative to the early onset of familial PD. Here, we report the cryo-EM structure of an α-syn fib...

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Udgivet i:Nat Commun
Main Authors: Zhao, Kun, Li, Yaowang, Liu, Zhenying, Long, Houfang, Zhao, Chunyu, Luo, Feng, Sun, Yunpeng, Tao, Youqi, Su, Xiao-dong, Li, Dan, Li, Xueming, Liu, Cong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250837/
https://ncbi.nlm.nih.gov/pubmed/32457390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16386-3
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