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Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using Light-Activated Guide RNA

[Image: see text] A light-activated gRNA allows for precise spatiotemporal control of gene editing in both mammalian cells and zebrafish embryos, with excellent off to on switching. This highly programmable approach can be easily adapted to any desired target sequence and can be delivered to a varie...

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Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Zhou, Wenyuan, Brown, Wes, Bardhan, Anirban, Delaney, Michael, Ilk, Amber S., Rauen, Randy R., Kahn, Shoeb I., Tsang, Michael, Deiters, Alexander
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250724/
https://ncbi.nlm.nih.gov/pubmed/32160370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201914575
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