SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

Klebsiella pneumoniae is a respiratory, blood, liver, and bladder pathogen of significant clinical concern. We show that the adaptor protein, SKAP2, is required for protection against K. pneumoniae (ATCC 43816) pulmonary infections. Skap2-/- mice had 100-fold higher bacterial burden when compared to...

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Publicado en:eLife
Autores principales: Nguyen, Giang T, Shaban, Lamyaa, Mack, Matthias, Swanson, Kenneth D, Bunnell, Stephen C, Sykes, David B, Mecsas, Joan
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250567/
https://ncbi.nlm.nih.gov/pubmed/32352382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56656
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