Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection

Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject 6–7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine phosphatase that causes dephosphorylation of the adaptor protein SKAP2, among other targets in neutrophils. SKAP2 functi...

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Publicado en:PLoS Pathog
Autores principales: Shaban, Lamyaa, Nguyen, Giang T., Mecsas-Faxon, Benjamin D., Swanson, Kenneth D., Tan, Shumin, Mecsas, Joan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241846/
https://ncbi.nlm.nih.gov/pubmed/32392230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008576
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