EZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin

BACKGROUND: The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repressor and is an epigenetic regulator for several cancers. However, the role of EZH...

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Detalhes bibliográficos
Publicado no:Cell Div
Main Authors: Chen, Si-qi, Li, Jia-qi, Wang, Xiao-qiao, Lei, Wen-jing, Li, Hao, Wan, Jiao, Hu, Zheng, Zou, Yao-wei, Wu, Xiao-yu, Niu, Hong-xin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249628/
https://ncbi.nlm.nih.gov/pubmed/32508971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13008-020-00064-3
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