Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment

Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK) pathway. Here, we demonstrate that miRNA-mediated silencing...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Rep Med
Main Authors: Izreig, Said, Gariepy, Alexandra, Kaymak, Irem, Bridges, Hannah R., Donayo, Ariel O., Bridon, Gaëlle, DeCamp, Lisa M., Kitchen-Goosen, Susan M., Avizonis, Daina, Sheldon, Ryan D., Laister, Rob C., Minden, Mark D., Johnson, Nathalie A., Duchaine, Thomas F., Rudoltz, Marc S., Yoo, Sanghee, Pollak, Michael N., Williams, Kelsey S., Jones, Russell G.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249503/
https://ncbi.nlm.nih.gov/pubmed/32478334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100014
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares