Combined Effect of Antiretroviral Therapy and Blockade of IDO in SIV-Infected Rhesus Macaques

Increased activity of IDO, which catalyzes the degradation of Trp into kynurenine (Kyn), is observed during HIV/SIV infection, and it may contribute to the persistence of HIV/SIV by suppressing antiviral T cell responses. We administered the IDO inhibitor 1-methyl-D-tryptophan (D-1mT) for 13 days to...

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Publicado no:J Immunol
Main Authors: Boasso, Adriano, Vaccari, Monica, Fuchs, Dietmar, Hardy, Andrew W., Tsai, Wen-Po, Tryniszewska, Elzbieta, Shearer, Gene M., Franchini, Genoveffa
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249223/
https://ncbi.nlm.nih.gov/pubmed/19299731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803314
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