Immune Activation Driven by CTLA-4 Blockade Augments Viral Replication at Mucosal Sites in Simian Immunodeficiency Virus Infection

The importance of chronic immune activation in progression to AIDS has been inferred by correlative studies in HIV-infected individuals and in nonhuman primate models of SIV infection. Using the SIV(mac251) macaque model, we directly address the impact of immune activation by inhibiting CTLA-4, an i...

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Hauptverfasser: Cecchinato, Valentina, Tryniszewska, Elzbieta, Ma, Zhong Min, Vaccari, Monica, Boasso, Adriano, Tsai, Wen-Po, Petrovas, Constantinos, Fuchs, Dietmar, Heraud, Jean-Michel, Venzon, David, Shearer, Gene M., Koup, Richard A., Lowy, Israel, Miller, Christopher J., Franchini, Genoveffa
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768121/
https://ncbi.nlm.nih.gov/pubmed/18390726
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